Design hydrophobic amino acids 4 carbons 100% alkyl groups
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Also, compound 7a caused a potent inhibitory effect on smooth muscle proliferation.
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The immunomodulatory effect of compound 7a, the most active member, showed a reduction in TNF- α by 87%. Furthermore, compound 7a arrested the cell cycle in the G2/M phase with induction of apoptosis. In addition, Bax and Bcl-2 concentration levels showed an increase in the proapoptotic protein Bax (261.4 Pg/ml) and a decrease of the antiapoptotic protein Bcl-2 (1.25 Pg/ml) compared to the untreated cells. Compound 7a, which is the most potent candidate, revealed a significant increase in caspase-3 level by 7.80-fold when compared to the control. Promising results encouraged us to additionally evaluate the most active members for their in vitro VEGFR-2 inhibitory effect. The new compounds were all screened against a panel of three cell lines (HepG-2, HCT-116, and MCF-7).
DESIGN HYDROPHOBIC AMINO ACIDS 4 CARBONS 100% ALKYL GROUPS SERIES
In order to discover novel VEGFR-2 TK inhibitors, we have designed and synthesized three new series of pyridine-containing compounds. VEGFR-2 blockage is a good approach for suppression of angiogenesis. VEGF is the key modulator for the initial stages of angiogenesis that acts through the endothelial-specific receptor tyrosine kinases (VEGFRs). In addition, angiogenesis is one of the hallmarks of cancerous growth. Vascular endothelial growth factor (VEGF) has been shown to stimulate VSMC proliferation. Abnormal vascular smooth muscle cell (VSMC) proliferation has an important role in the pathogenesis of both atherosclerosis restenosis and hypertension.